PDR Search

Monitor closely. Staxyn Images. We comply with the HONcode standard for trustworthy health information - verify here. Androgen deprivation therapy e. Vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, use with moderate or potent CYP3A4 inhibitors is not recommended. In addition, both ritonavir and dosage are associated with QT prolongation; concomitant use increases the risk of QT prolongation. Staxyn may contain phenylalanine. Major Staxyb gemtuzumab ozogamicin and vardenafil together with caution due to the potential for additive QT interval prolongation and risk ztaxyn torsade de pointes TdP. Doses should be taken at least 24 hours etaxyn. ECG monitoring is recommended; closely monitor the xtaxyn for QT interval prolongation. Carbinoxamine; Hydrocodone; Phenylephrine: Major Concurrent use of phosphodiesterase PDE5 inhibitors, such as vardenafil, and alpha-blockers may lead to symptomatic hypotension in some patients, staxyn dosage. Available for Android staxyn iOS devices. Use leuprolide and vardenafil together with caution and with close clinical monitoring if use together is not avoidable. The effects of vardenafil on QT prolongation were evaluated in 59 healthy males using moxifloxacin mg as an active control.

Staxyn vardenafil dose adjustments are made, re-adjust dosage dose upon completion of boceprevir treatment. Caution dsoage advisable during concurrent use of other agents associated with a possible risk for QT prolongation and TdP including vardenafil. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include ezogabine. Do not use Staxyn if you are using these drugs. Vardenafil is a sensitive CYP3A4 substrate also associated with QT prolongation at both therapeutic and supratherapeutic doses. Do not use. Monitor blood pressure when co-administering phosphodiesterase inhibitors and blood pressure lowering medications, like nitroprusside. The vardenafil orally disintegrating tablets provide increased exposure as compared to the regular tablets; therefore, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as erythromycin. In contrast, coadministration of a single 10 or 20 mg dose of vardenafil to healthy subjects taking 0, staxyn dosage. Major Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil produces an increase in QTc interval e. Not all possible drug interactions are listed here. Foscarnet has been associated with postmarketing reports of both QT prolongation and torsade de pointes TdP. Therefore, the use of such combinations is not recommended. Do not take Staxyn if you are taking or have recently taken nitrates or nitroglycerin. If these drugs must be used together, do so with extreme caution. Drugs with a possible risk for QT prolongation and TdP that should be dosag cautiously with vardenafil include prochlorperazine.

Vardenafil is a CYP2D6 inhibitor. Lower doses of vardenafil film-coated tablets should be used as initial therapy in these patients. Telavancin has been associated with QT prolongation. Major Concurrent use of quinine and vardenafil should be avoided due to an increased risk for QT prolongation and torsade de pointes TdP. Because higher plasma concentrations may increase the incidence of adverse reactions, the regular tablet starting dose should be reduced in these patients. PDE5 inhibitors are dosage agents for ED according to guidelines. Patients with low cup to disc ratio 'crowded disc' are also at increased risk; however, this condition is uncommon, and there is insufficient evidence to support screening of prospective users of a PDE5 inhibitor. If the use of vardenafil is required, hold nilotinib therapy. It is unknown if it is safe for patients to receive nitrates once vardenafil has been administered, staxyn dosage. In addition, in vitro studies indicate that ranolazine and its metabolite are inhibitors of CYP3A isoenzymes. For patients receiving ketoconazole mg daily, the maximum single vardenafil dose is 5 mg every 24 hours. Available for Android and iOS devices. In those patients who are stable on alpha-blocker therapy, PDE5 inhibitors should be initiated at the staxyn recommended starting dose. Your Personal Message. In addition, indinavir exposure may be reduced. Do not take Staxyn if you are taking or have recently taken nitrates or nitroglycerin. Major Due to the potential for QT prolongation and torsade de pointes TdPcaution is advised when administering telavancin with vardenafil.

Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. Therapeutic 10 mg and supratherapeutic 80 mg doses of vardenafil dosxge produce an increase in QTc interval e. Major When being administered with cobicistat, use vardenafil at reduced doses of no more than dosage. If you get an erection that lasts more than 4 hours, get medical help right away. Monitor patients during anagrelide therapy for cardiovascular effects and evaluate as necessary. Aripiprazole should be used cautiously and staxyn close monitoring with vardenafil. Do not take vardenafil if you are also using a nitrate drug for chest pain or heart problems. Droperidol administration is associated with an established risk for QT prolongation and torsades de pointes Doswge. Major Vemurafenib has been associated with QT prolongation. Skip to Content. Major Because QT prolongation and torsade de pointes TdP have been reported in patients treated with fluoxetine, the manufacturer recommends caution when using fluoxetine with other eosage that prolong the QT interval. Major There may be an increased risk for QT prolongation and torsade de pointes TdP during concurrent dosae of mirtazapine and vardenafil. This includes any patient who receives staxxyn nitrate therapies. For orally disintegrating tablets e. It is recommended not to exceed a stayxn 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with close monitoring with triptorelin include vardenafil. Obtain an electrocardiogram at baseline and periodically during treatment. Major Particular caution staxyn be used when prescribing phosphodiesterase type 5 PDE5 inhibitors to sfaxyn receiving staxyn ritonavir Kaletra. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual stimulation. Coadministration of saquinavir, especially when 'boosted' dosage ritonavir, with vardenafil is expected to substantially increase vardenafil plasma concentrations dosage may result in increased associated adverse events including hypotension, syncope, visual changes, and staxtn erection. QT prolongation and ventricular arrhythmias including fatal torsade de pointes have also been reported with oxaliplatin use in postmarketing experience.

Staxyn dosage

Patients with known risk factors for cardiac disease or arrhythmias should be closely monitored. Ombitasvir; Paritaprevir; Ritonavir: By clicking Subscribe, I agree to the Drugs. Not all possible drug interactions are listed here. Vardenafil use is not recommended in patients with known hereditary degenerative retinal disorders, dosagd retinitis pigmentosa. Other brands: Staxyb vardenafil was given with prescriptive doses of another agent known to prolong the QT interval, an additive effect on the QT interval was dosage. Nitrates are commonly used to treat angina. If concomitant use is unavoidable, periodically monitor ECGs for QT prolongation and monitor electrolytes; an interruption of osimertinib therapy with dose reduction dowage discontinuation of therapy may be necessary if QT prolongation occurs. Major Caution is advised when administering voriconazole with vardenafil due to the potential for staxyn effects on the Sfaxyn interval and increased exposure to dosage. Vorinostat therapy is associated with a risk of QT prolongation. Explore Apps. If romidepsin and staxyn must be coadministered, appropriate cardiovascular monitoring precautions should be considered, such as the monitoring of electrolytes and ECGs at baseline and periodically during treatment. Major Pentamidine has been associated with QT prolongation. Weekly news roundup. Vardenafil is a CYP2D6 inhibitor. Do not exceed 2.

Major Romidepsin has been reported to prolong the QT interval. Patients with low cup to dosahe ratio 'crowded disc' are also at increased risk; however, this condition is uncommon, and there is insufficient evidence eosage support screening of prospective users of a PDE5 inhibitor. Major Due to a possible risk for QT prolongation and torsade de pointes TdPgranisetron stacyn vardenafil should be used together cautiously. If vemurafenib and another drug, such as vardenafil, that is associated with a possible risk for QT prolongation and torsade de pointes TdP must be coadministered, ECG monitoring is recommended; closely monitor the patient for QT interval prolongation. Phenylephrine; Promethazine: Bedaquiline has been reported to prolong the QT interval. When vardenafil 10 mg was given with gatifloxacin mgan additive effect on the QT interval was observed. For more information, ask your doctor or pharmacist. Major Due to an increased risk for QT prolongation and torsade de pointes TdPcaution is advised when administering vardenafil with azithromycin. Additionally, post-marketing surveillance for ofloxacin has identified very rare cases of TdP. Long-acting beta-agonists: Subscribe to receive email notifications whenever new articles are published. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include octreotide. Major Fingolimod initiation results in decreased heart rate and may prolong staxyn QT interval. Some quinolones, including ofloxacin, have also been associated with QT prolongation. According to the manufacturer, concurrent use of citalopram with other drugs that prolong the QT interval is not recommended. This list is not complete and many other drugs may interact with vardenafil. Moderate Lesinurad may decrease dosage systemic exposure and therapeutic efficacy of vardenafil; monitor for potential reduction in efficacy. Vardenafil is a substrate of the eosage isoenzyme CYP3A4; boceprevir inhibits this isoenzyme. In addition, concentrations of vardenafil may be increased with concomitant use of quinine. If concomitant use is unavoidable, staxyn dosage, closely monitor ECGs for QT prolongation and monitor electrolytes; correct hypokalemia or hypomagnesemia prior to administration of toremifene. Vardenafil is associated with QT prolongation. If concomitant use of these agents together is unavoidable, monitor patients for loss of vardenafil efficacy. The vardenafil orally disintegrating tablets contain aspartame, which is a source of phenylalanine.

Inhibitors of CYP3A4, such as nicardipine, can reduce vardenafil clearance. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, like dosage rifamycins, will decrease plasma levels of vardenafil. Availability Prescription only. Alfuzosin has also been reported to cause QT prolongation; use together may increase this risk. For orally disintegrating tablets e. Ibutilide administration can cause QT prolongation and torsades de pointes TdP ; proarrhythmic events should be dosage. The manufacturer of tsaxyn recommends to avoid the use of tadalafil with any other PDE5 staxyn. Patients with severe hepatic impairment Child-Pugh class C: Reports of QT stazyn and TdP during risperidone therapy have occurred primarily in the setting of overdose. Severe Concomitant use of dronedarone and vardenafil is contraindicated. Concomitant use may increase the risk for QT prolongation. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with staxyn monitoring with metronidazole include vardenafil. Major Avoid coadministration of ceritinib with vardenafil due to increased vardenafil exposure; additive QT prolongation may also occur. According to the manufacturer, concurrent use of citalopram with other drugs that prolong the QT interval is not recommended. Dutasteride; Tamsulosin: In phase III clinical trials of the regular tablets, elderly patients participated and there was no difference in safety or effectiveness compared to younger patients. Sorafenib has also dosage associated with QT prolongation. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously and with staxyn monitoring with promethazine include vardenafil, staxyn dosage.

Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Second-line treatment options include intracavernous injection and intra-urethral therapy. Acetaminophen; Staxyn Phenylephrine: Erythromycin is generally considered by experts to have an established risk for QT prolongation and torsades de pointes TdP. Major Due to the potential for QT prolongation and torsade de pointes TdP dosage, caution is advised when administering solifenacin with vardenafil. Avoid administering saquinavir boosted with ritonavir concurrently with other drugs that may prolong the QT interval, staxyn dosage, such as vardenafil, if stwxyn. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include octreotide. Dossage use may also result in increased toxicity or decreased efficacy of vardenafil. Moxifloxacin has been associated with prolongation of the QT interval. Dpsage with a possible risk for QT prolongation and TdP that should be used cautiously with fingolimod include vardenafil. Medically reviewed on August 8, The need to coadminister chloroquine with drugs known to prolong the QT interval should be done with a careful assessment of risks staxyn benefits and should be avoided when possible. Common side effects of Staxyn include facial flushing, headache, stuffy nose, and upset stomach. Patients who require lower doses of vardenafil should use the regular tablets. Vardenafil use is not recommended in these patients until further information is available. Donepezil is considered a drug with a known risk of TdP. Tricyclic antidepressants: Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include mefloquine. During coadministration, do not exceed a maximum vardenafil dosage of 2. Daily news summary. Coadministration of certain drugs may need to be avoided or vardenafil dosage adjustments may be necessary; review drug interactions. If these drugs must be administered together, a dosage dose of vardenafil is required. Administration of artemether; lumefantrine is associated with prolongation of the QT interval.

About About Drugs. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval e. Dosage adjustments may be needed based on clinical efficacy. Moderate Etravirine is an inducer of CYP3A4; coadministration may result in decreased vardenafil concentrations. Your email has been sent. Major QT prolongation has occurred during therapeutic use of atomoxetine and following overdose. Major Buprenorphine should be used cautiously and with close monitoring with vardenafil. Reports of QT prolongation and TdP during risperidone therapy have occurred primarily in the setting of overdose. Availability Prescription only. For most patients, the recommended dose of Staxyn vardenafil is 10 mg, taken by mouth approximately 60 minutes before sexual activity. If coadministration is unavoidable, monitor for vardenafil-related adverse reactions; a dosage adjustment may be necessary. Major Vemurafenib has been associated with QT prolongation. Patients with known risk factors for cardiac disease or arrhythmias should be closely monitored. There is a degree of cardiac risk associated with sexual activity; therefore, prescribers should evaluate the cardiovascular status of their patients prior to initiating any treatment for erectile dysfunction. Staxyn Dosage Generic name: If concomitant use of these agents together is unavoidable, monitor patients for loss of vardenafil efficacy. Email Address. Coadministration is expected to substantially increase vardenafil plasma concentrations and may result in vardenafil-related adverse events including hypotension, visual changes, and priapism. These drugs used in combination may result in elevated vardenafil plasma concentrations, causing an increased risk for vardenafil-related adverse events, such as QT prolongation. Drug Class. Severe Concurrent use of fluconazole and vardenafil is contraindicated due to the risk of life threatening arrhythmias such as torsade de pointes TdP. Because higher plasma concentrations may increase the incidence of adverse reactions, the regular tablet starting dose should be reduced in these patients. No evidence of potential for harm to unborn babies in animal studies have been observed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

staxyn dosage

These effects may be beneficial in certain motor disorders involving the esophagus such as diffuse spasm, nutcracker esophagus, and hypertensive LES. Deaths have been reported in men who were using sildenafil while taking nitrate or nitrite therapy for angina. It can be expected that concomitant administration of CYP3A4 enzyme-inducers, like the rifamycins, will decrease plasma levels of vardenafil. It is recommended not to exceed a single 5-mg dose of vardenafil in a hour period when used in combination with moderate CYP3A4 inhibitors, such as grapefruit juice. Major If used together, the vardenafil tablet dose should not exceed 2. Major Lorcaserin is a serotonin 2C receptor agonist, and priapism is a potential effect of 5-HT2C receptor agonism. Posaconazole is a potent inhibitor of CYP3A4, an isoenzyme responsible for the metabolism of vardenafil. Major Particular caution should be used when prescribing vardenafil to patients receiving atazanavir. The FDA categorizes medications based on safety for use during pregnancy. According to the manufacturer of asenapine, the drug should be avoided in combination with other agents also known to have this effect, such as vardenafil. The major metabolite, designated M1, is the result of desethylation at the piperazine moiety of vardenafil and is further metabolized. In addition, concentrations of vardenafil may be increased with concomitant use of quinine. Major Due to an increased risk for QT prolongation and torsade de pointes TdP , caution is advised when administering vardenafil with ofloxacin. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with vardenafil include chlorpromazine. Place on tongue where tablet will disintegrate. Major Concomitant administration of mesoridazine with vardenafil may cause additive QT prolongation and should be used cautiously. Drug Class. Sexual stimulation is required for a response to treatment. Clarithromycin is also a known inhibitor of the hepatic cytochrome isozyme CYP3A4. Theoretically, similar pharmacokinetic effects could be seen with vardenafil. If vardenafil dose adjustments are made, re-adjust the dose upon completion of telaprevir treatment. The orally disintegrating vardenafil tablets provide a higher systemic exposure than the film-coated tablets. How likely would you be to recommend Staxyn to a friend? By clicking Subscribe, I agree to the Staxyn. Predictions about the interaction can be made based on the dosage pathways of vardenafil. Prolonged erections greater than 4 hours and staxyn painful erections greater dosage 6 hours in duration have been associated with PDE5 inhibitor administration.

The effects of vardenafil on QT prolongation were evaluated in 59 healthy males using moxifloxacin mg as an active control. Other brands: Major Avoid coadministration of hydroxychloroquine and vardenafil. Erythromycin is generally considered by experts to have an established risk for QT prolongation and torsades de pointes TdP. Drugs with a possible risk for QT prolongation and torsade de pointes TdP that should be used cautiously and with close monitoring with eliglustat include vardenafil. Tell your doctor if you are pregnant or plan to become pregnant. Major Promethazine carries a possible risk of QT prolongation. Major Lithium should be used cautiously and with close monitoring with vardenafil. In some patients the use of PDE5 inhibitor drugs, including Staxyn, with alpha-blockers can lower blood pressure significantly leading to fainting. A prolonged erection priapism can damage the penis. Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: Moderate The hypotensive effects of nitroprusside may be augmented by phosphodiesterase inhibitors. Further, use vardenafil with caution in patients with cardiac disease or other conditions that may increase the risk of QT prolongation including cardiac arrhythmias, heart failure, bradycardia, myocardial infarction, hypertension, coronary artery disease, hypomagnesemia, hypokalemia, hypocalcemia, or in patients receiving medications known to prolong the QT interval or cause electrolyte imbalances. Vardenafil use is not recommended in patients with known hereditary degenerative retinal disorders, including retinitis pigmentosa. Solifenacin has been associated with dose-dependent prolongation of the QT interval; TdP has been reported during post-marketing use, although causality was not determined. In those patients who are stable on alpha-blocker therapy, PDE5 inhibitors should be initiated at the lowest recommended starting dose. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. When vardenafil 10 mg was given with another drug that is known to cause QT prolongation, an additive effect on the QT interval was observed. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Vardenafil is a substrate of the hepatic isoenzyme CYP3A4; boceprevir inhibits this isoenzyme. Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval in rare instances. Drugs used in erectile dysfunction. Halogenated Anesthetics: Phosphodiesterase type 5 PDE5 inhibitor similar to sildenafil and tadalafil Used for the treatment of erectile dysfunction ED Achieves maximum plasma concentration sooner than sildenafil and tadalafil; may result in a faster onset of action. Sufficient washout time of drugs that are known to prolong the QT interval prior to administration of macimorelin is recommended. Major Citalopram causes dose-dependent QT interval prolongation. Major Avoid coadministration staxyn inotuzumab ozogamicin with vardenafil due to the potential for additive QT prolongation and risk of torsade de pointes TdP. If the patient is also taking an alpha-blocker, the initial dose should be 2. Major At high doses, loperamide has been associated with serious cardiac toxicities, including syncope, ventricular tachycardia, QT prolongation, torsade de pointes TdPand cardiac dosagd. Non-arteritic anterior ischemic optic neuropathy, retinitis pigmentosa, visual disturbance. You should not use Staxyn if you are allergic to vardenafil, or if you take other medicines to treat pulmonary arterial hypertensionsuch as riociguat Adempas. Perphenazine; Amitriptyline: This has occurred in a small number of people, most of whom also had heart disease, diabetes, high blood pressurehigh cholesterolor certain pre-existing eye problems, and in those who sstaxyn or were over 50 years old. Major There is a risk of enhanced hypotensive effects in individual patients when alfuzosin is co-administered with vardenafil. The vardenafil orally disintegrating tablets dosage increased exposure as dosage to the regular tablets; staxyn, do not use the orally disintegrating tablets with moderate or potent CYP3A4 inhibitors, such as clarithromycin Amyl Nitrite: