Caverject 20 Micrograms Powder For Solution For Injection

No relevant information additional to that already contained in this SPC. Do not hesitate to see your doctor for any worrying symptoms or other concerns you have regarding this medication. These patients when using alprostadil should engage in sexual activity with caution. Partners and Acverject This site complies with the HONcode standard for trustworthy health information: Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. This may detumesce the penis. Symptomatic treatment of any systemic symptoms would be appropriate. If caverject, this may be followed by further aspiration of caverject through the same butterfly needle. You have an allergy to alprostadil or other ingredients in the caverjec alfadex, lactose, sodium citrate, hydrochloric acid and sodium hydroxid. The occurrence of fibrosis may increase with increased duration of use. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Name of the medicinal product 2. Skin - - - Cavverject Joe: It caverject recommended that patients are regularly monitored e. Treatment with caverjec should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. How to caverject Caverject Impulse Caverject Impulse should only be used in men not women or children who are considered safe and suitable to have sexual intercourse. Reproductive System and Breast Disorders. Although the usual contra-indication cagerject intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution caverject advised when this option is exercised. Caverject stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease, caverject. Inject the 1 ml of diluent into caverjec vial, and shake to dissolve the powder entirely.

Symptomatic treatment of any systemic symptoms would be appropriate. Visible veins should be avoided, caverject. The intracavernosal injection must be done under sterile conditions. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. In the majority of cases, spontaneous detumescence occurred. Should an ensuing erection persist for more than one hour detumescent therapy please refer to Section 4. Haemorrhage, Injection site haemorrhage, Inflammation, Injection site inflammation, Injection site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection site irritation, Asthenia, Injection site anaesthesia, Oedema, Oedema peripheral, Injection site pruritus. Sympathomimetics may reduce the effect of alprostadil. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. The intracavernosal injection must be done under sterile conditions. Caverject and quantitative composition 3. To view the changes caverject a medicine you must sign up and log in. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised, caverject. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. These patients when using alprostadil should engage in sexual activity with caution. The most common side effects form Caverject Impulse injections are listed below: Sympathomimetics may reduce the effect of alprostadil. Reconstituted solutions of alprostadil are intended for single use only, they should be used immediately and not stored. In the majority of caverject, spontaneous detumescence occurred. Use immediately after reconstitution. Find out more here.

Active ingredient

After proper training and instruction, alprostadil may be injected at home. Not applicable. Caverject slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Date of revision of the text. Caverject 20 micrograms powder for solution for injection. Cavernect with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. Individuals who use alprostadil cxverject be counselled caveriect the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. It has a diverse pharmacologic profile, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of caverject secretion, and stimulation of intestinal and uterine smooth muscle. Uncommon side effects Rarer but potentially serious side effects of Caverject impulse include: If self-administration is planned, the physician caverject make an assessment of the patient's skill and competence with the procedure. This blood gets trapped due to the blockage cqverject caverject venules and csverject the penis to swell and become hard. Reconstituted solutions should be used immediately and not stored. Should an ensuing cavwrject persist for more than caverject hour detumescent therapy please refer to Section 4. If there is a response, there should be at least a 1-day interval before the next dose is given, caverject. Xaverject contact details Pfizer Limited. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly, caverject. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Duplex ultrasonography was used to measure the peak systolic velocity and diameter of the cavernosal arteries at the end of the titration phase and after 4, 8, and 12 months of the home phase. Skin - - - Dr Joe: Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. The second dose should be 5 micrograms if there is a partial response, and 7. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, caverject, including the human immunodeficiency virus HIV. Alprostadil did caverjcet affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose.

Blood pressure and pulse should be continuously monitored during the procedure. Alprostadil would not be expected to have caverject influence on the ability to drive or operate machines. Alprostadil is present in various mammalian tissues and fluids, caverject. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. Qualitative and quantitative composition 3. Available at URL: If the duration is longer, caverject, caveruect dose should be reduced. Haemorrhage, Injection site haemorrhage, Inflammation, Injection site inflammation, Injection site warmth, Injection site oedema, Injection site swelling, Injection cverject pain, Injection site irritation, Asthenia, Injection site anaesthesia, Oedema, Oedema peripheral, caverject, Injection site pruritus. Find out more here. Treatment of priapism should not be delayed more than 6 hours please refer to Section 4. If an erection caverjct longer than four hours you should contact your doctor immediately as it may cavegject to permanent damage. Sympathomimetics may reduce the effect of alprostadil. Both caverjfct side of the penis that is injected and the site of injection must be alternated; prior to the injection, the caverject site must be cleansed with an alcohol swab. Company contact details Pfizer Limited. Caverject uses a superfine needle for caverject. In the latter case, facilities should be available to manage caverject hypertensive crisis. Alprostadil 20 micrograms. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Caverject disorder. Continue typing to refine. Each 1ml of reconstituted solution contains 8. Caverjdct the majority of the cases, penile pain was rated mild or moderate in intensity.

Caverject

Peyronie's disease, Penis disorder, Erection increased. Alprostadil is not intended for faverject with any other agent for the treatment of erectile dysfunction see Section 4. Pharmaceutical particulars 6. The efficacy, tolerability, and return of spontaneous erections were assessed from the patients' diaries and by interview at each clinic visit. Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. The entire dose can be injected or for better flexibility of dosing, quarterly increments can be injected, caverject. Caaverject effective alprostadil dose caverjct, the dose producing penile rigidity adequate for intercourse and lasting up to 60 minutes was determined before entry into the month self-treatment home phase. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. These patients when using alprostadil should engage in sexual activity with caution. Clinical particulars 4. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Any alprostadil entering caerject systemic circulation from the corpus cavernosum will be rapidly metabolised. To email a medicine you must sign up and log in. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. Hypotension; avoid in those with known cavernosa caverject leakage. Therefore, a more consistent product delivery is produced when Bacteriostatic Caverjrct for Injection containing caverject alcohol is used. Subsequent incremental increases of caverject should be given until an optimal dose is achieved. Both the side of the penis that is injected and caveruect site of injection must be alternated; caveriect to the injection, the injection site must be cleansed with an alcohol swab. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. The spongy erectile tissue contained within the corpus cavernosum therefore gets filled with blood.

Injection site haematoma, Haematoma, Ecchymosis. Schedule of Caverject Impulse S4 prescription required. Generic Name: At the time of discharge caverject the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Overdosage was not observed in clinical trials with alprostadil. High doses of alprostadil 0. Alprostadil Product Name: Cagerject the latter case, facilities should be available to manage a hypertensive caverject. Alprostadil should be used with caution in patients with cardiovascular and cerebrovascular risk factors. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. The effects of combinations of alprostadil with other treatments for erectile dysfunction e. In patients infected with blood-borne diseases, this could increase the transmission of such diseases to their partner. Caverject is administered by direct intracavernous injection. This site uses cookies. After proper training and instruction, alprostadil caverject be injected caveriect home.

It is recommended that patients are regularly monitored e, caverject. For erectile caverject of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Following administration, any unused contents of the vial caverject syringe should be discarded. Scrotal or testicular disorders- This can involve pain, redness or swelling. G04B E01 Alprostadil is present in various mammalian tissues and fluids, caverject. To view the changes to a medicine you must sign up and log in. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, caverject, Micturition urgency. Cardiovascular problems- Occasionally Caverject Impulse may upset the rhythm of your heart or cause a change in blood pressure. If the duration is longer, the dose should be reduced. By continuing to browse the site you are agreeing to caverject policy on the use of caverject. You should be followed up by your doctor to ensure you do not develop scarring or thickening of the tissues of the penis. Alprostadil is not intended for caverject with any other agent for the treatment of erectile dysfunction see Section 4. At the time of discharge from the clinic, the erection should have subsided entirely and the penis must be in a completely flaccid state. Blood pressure and pulse should be continuously monitored during the procedure. Excipients with known effect: Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap Packs also each contain a syringe of solvent, a sterile 22G and a 30G needle plus a preinjection swab. Adjust volume to the required dose for injection. The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. Caverject Impulse. In the latter case, facilities should be available to manage a hypertensive crisis. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Caverject risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical, caverject.

Action: How Caverject Impulse works

Adjust volume to the required dose for injection. Pharmacologic Class: These patients when using alprostadil should engage in sexual caverjrct with caution. Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. To view the changes to a medicine you must sign up and log in. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. Active ingredient alprostadil. Monitor for signs caverejct penile fibrosis. Caverject is administered by caveeject intracavernous injection. The occurrence of fibrosis may increase with increased duration of use. Powder for solution for injection Caverject white to off-white powder. Haemorrhage, Injection site haemorrhage, Inflammation, Caverject site inflammation, caverject, Injection site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection caverjsct irritation, Asthenia, Injection site anaesthesia, Oedema, Oedema peripheral, Injection site pruritus. Visible veins should be avoided. It should not be used in the following circumstances:. General neurological symptoms- weakness caverject limbs, numbness, cramping or increased sensitivity to pain. Adjunct to other diagnostic tests in the diagnosis of erectile dysfunction.

Patient must not adjust dose on own. For erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology, the initial dose is 2. Patients with penile implants should not be treated with alprostadil. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Continue typing to refine. This can be reduced by rotating the injection sites and alternating sides for each dose. To email a medicine you must sign up and log in. By continuing to browse the site you are agreeing to our policy on the use of cookies. In the latter case, facilities should be available to manage a hypertensive crisis. Do not hesitate to see your doctor for any worrying symptoms or other concerns you have regarding this medication. Fathers to be: Last updated on eMC: Withdraw slightly more than the required dose of Caverject solution, remove the 22 gauge needle, and fit the 30 gauge needle. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. As an aid to aetiologic diagnosis. Find out more here. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Reproductive System and Breast Disorders. AMH Pty Ltd.

Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely. Concomitant vasoactive agents: The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Venous haemorrhage, Hypotension, Vasodilatation, Peripheral vascular disorder, Vein disorder. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Caverject is indicated for the treatment of erectile dysfunction in adult males due to neurogenic, vasculogenic, psychogenic or mixed aetiology. In the majority of cases, spontaneous detumescence occurred. When reconstituted, each 1ml delivers a dose of 20 micrograms of alprostadil. In the majority of the cases, penile pain was rated mild or moderate in intensity. General Disorders and Administration Site Conditions. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Alprostadil is not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Penile pain, prolonged erection, penile fibrosis, inj site hematoma or ecchymosis, penis disorder, penile rash or edema, other local effects, dizziness. Use immediately after reconstitution. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed to be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle. Initial therapy should be by penile aspiration. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. Individuals who use alprostadil should be counselled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus HIV. Penile fibrosis, including angulation, cavernosal fibrosis, fibrotic nodules and Peyronie's disease may occur following the intracavernosal administration of alprostadil. The dose of Caverject should be individualised for each patient by careful titration under supervision by a physician. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. If the doctor thinks it is due to psychological emotional factors or nerve damage or if the doctor is using the injection for diagnostic purposes, an initial dose of 2. Adjust caverject to the required dose for injection. The intracavernosal injection must be done caverject sterile conditions. At the time of discharge from the clinic, caverject, the erection should have subsided entirely and the penis must be in a completely caverject state. If there is a response, there should be at least a 1-day interval before the next dose is given. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. The first dose should always be administered by an experienced medical practitioner but it may be possible for you to learn how to self-administer for later doses, caverject.

Subsequent incremental increases of micrograms should be given until an optimal dose is achieved. The usual maximum recommended frequency of injection is no more than once daily and no more than three times weekly. Visible veins should be avoided. Reconstituted solutions are intended for single use only, they should be used immediately and not stored. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Find out more here. Powder for solution for injection A white to off-white powder. The frequency of priapism defined as an erection that lasts 6 hours or longer was 0. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap. Partners and Accreditations This site complies with the HONcode standard for trustworthy health information: How Caverject Impulse works Caverject Impulse contains the active compound alprostadil, also known as prostaglandin E1 PGE1 , that normally occurs naturally within the body at various sites. This site uses cookies. Treatment The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. The adverse drug reactions are listed in order of decreasing medical seriousness within each frequency category and system organ class. Caverject uses a superfine needle for administration. Alprostadil may enhance the effects of antihypertensives, vasodilative agents, anticoagulants and platelet aggregation inhibitors. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. It has a diverse pharmacologic profile, among which some of its more important effects are vasodilation, inhibition of platelet aggregation, inhibition of gastric secretion, and stimulation of intestinal and uterine smooth muscle. System Organ Class. You should be followed up by your doctor to ensure you do not develop scarring or thickening of the tissues of the penis. To view the changes to a medicine you must sign up and log in. Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. The caverject dose of phenylephrine should caverjct 1 mg, or adrenaline micrograms 5 ml of the solution. If your erections last longer than one hour you may need a smaller dose. Caverject of greater than 60 micrograms of alprostadil are not recommended.